MCAS and Fatigue

Why MCAS causes fatigue is a really good question. The reason I’m writing about it today is because I am so tired and there is no reason why. My kids are grown, my house is clean, my work is done, it’s time to wake up and enjoy…… yet I’m so tired and tired of being tired.

So I asked Lilly (our AI) – Does MCAS make you tired and why? Here is the answer.

Yes, Mast Cell Activation Syndrome (MCAS) can cause significant fatigue, and there are several reasons why it can lead to tiredness and low energy levels:

1. Histamine Release: One of the key features of MCAS is the release of histamine and other inflammatory mediators by overactive mast cells. Excess histamine in the body can lead to symptoms like fatigue, drowsiness, and brain fog. Histamine can affect neurotransmitter systems in the brain, contributing to fatigue.
2. Chronic Inflammation: MCAS is associated with chronic inflammation due to the release of pro-inflammatory substances by mast cells. Chronic inflammation can lead to a general sense of malaise and fatigue.
3. Gastrointestinal Symptoms: Many individuals with MCAS experience gastrointestinal symptoms, such as diarrhea, abdominal pain, and malabsorption. These symptoms can disrupt nutrient absorption, leading to nutritional deficiencies that can contribute to fatigue.
4. Sleep Disturbances: MCAS can be associated with sleep disturbances, including difficulty falling asleep, frequent awakenings, or restless legs syndrome. Poor sleep quality can result in fatigue.
5. Pain and Discomfort: MCAS-related pain, such as migraines, joint pain, and muscle pain, can be physically exhausting and contribute to fatigue.
6. Orthostatic Intolerance: MCAS can be associated with autonomic nervous system dysfunction, leading to conditions like postural orthostatic tachycardia syndrome (POTS). These conditions can result in symptoms like dizziness and fatigue upon standing.
7. Medications: Some of the medications used to manage MCAS, such as antihistamines and mast cell stabilizers, can have sedative side effects, contributing to feelings of fatigue.
8. Energy Expenditure: Individuals with MCAS may expend more energy due to the body’s constant battle against mast cell activation and inflammation. This increased energy expenditure can lead to fatigue.

It’s important to understand that MCAS is a complex and heterogeneous condition, and the specific factors contributing to fatigue can vary from person to person. The fatigue experienced by individuals with MCAS can be severe and chronic, significantly impacting their quality of life. Management of MCAS typically involves a combination of medications to stabilize mast cells and reduce symptoms, as well as lifestyle modifications to minimize triggers and optimize overall health. If you are experiencing fatigue related to MCAS, it is important to work with a healthcare provider who is knowledgeable about the condition to develop a tailored treatment plan.

With these answers, I can probably check off a few as being the culprit of my fatigue (how about you?). But, knowing the why doesn’t make it less easy to live with this fatigue.

I don’t want to be tired so much of the time. So back to Lilly…..

How to live with less fatigue while having MCAS?

Living with less fatigue while having Mast Cell Activation Syndrome (MCAS) can be challenging, but there are strategies and lifestyle modifications that may help improve your quality of life. Here are some tips to manage fatigue with MCAS:

1. Work with a Specialist: Consult with a healthcare provider who is knowledgeable about MCAS. They can help you develop a personalized treatment plan that may include medications and other interventions to manage your symptoms.
2. Identify and Avoid Triggers: Keep a symptom journal to identify specific triggers that worsen your fatigue. Common triggers can include certain foods, environmental factors, stress, or medications. Once identified, try to avoid or minimize exposure to these triggers.
3. Follow a Low-Histamine Diet: Some individuals with MCAS find relief from fatigue by following a low-histamine diet. This involves avoiding foods and beverages high in histamine, such as aged cheeses, processed meats, and alcohol.
4. Stay Hydrated: Gastrointestinal symptoms, like diarrhea, can lead to dehydration, which can exacerbate fatigue. Stay well-hydrated by drinking plenty of water. In some cases, electrolyte-rich beverages may be necessary.
5. Rest and Pace Yourself: Listen to your body and rest when needed. Avoid overexertion, and try to pace your activities to conserve energy. It’s important to find a balance between activity and rest.
6. Improve Sleep Hygiene: Create a sleep-friendly environment, establish a regular sleep schedule, and practice relaxation techniques to improve the quality of your sleep. Addressing sleep disturbances can help reduce fatigue.
7. Manage Stress: Stress can exacerbate symptoms and fatigue in individuals with MCAS. Explore stress-reduction techniques such as meditation, deep breathing exercises, yoga, or mindfulness.
8. Medication Management: Take prescribed medications as directed by your healthcare provider. Medications like mast cell stabilizers, antihistamines, and other treatments may help alleviate symptoms, including fatigue.
9. Exercise: Engage in gentle, low-impact exercise if your health allows. Exercise can help improve energy levels, but it’s essential to tailor your exercise routine to your individual capabilities.
10. Nutritional Support: Ensure you are meeting your nutritional needs by working with a healthcare provider or a registered dietitian. Nutritional supplements may be recommended to address potential deficiencies.
11. Support Groups: Join MCAS support groups or online communities where you can connect with others facing similar challenges. Sharing experiences and coping strategies can be beneficial.
12. Education and Advocacy: Educate yourself about MCAS and advocate for your healthcare needs. Understanding the condition can empower you to make informed decisions and communicate effectively with your healthcare team.

Remember that managing fatigue with MCAS is an ongoing process, and what works best for one person may not work for another. It’s essential to work closely with healthcare professionals and be patient as you explore different strategies to improve your energy levels and overall well-being.

So AI is great for certain answers but one thing I would like to add is LISTEN TO YOUR BODY. Your body should be giving you clues all the time. Ok, nothing like here’s the answer – you’re cured. But…. I found too much sugar can make me tired. And viola – I had a (one, numeral uno, only one) piece of Sees candy today as they just opened by us. That might be where my tiredness comes from. How about you? What makes you tired…. besides all that goes along with MCAS?

So off I go to #9 and try a little exercise…. then maybe a nap.

To Us! Love and Health!